I would say not that I have noticed! In 6x6 reversi, white achieves a narrow victory, so there is a suggestion (but no more than that) that white could have a very slight advantage at the larger games.
Please note, I am talking from a point of view where BLACK PLAYS FIRST as in reality!
(hide) If you want to find out more about some games you can check the links section and see if you find any interesting links there. (pauloaguia) (show all tips)