I would say not that I have noticed! In 6x6 reversi, white achieves a narrow victory, so there is a suggestion (but no more than that) that white could have a very slight advantage at the larger games.
Please note, I am talking from a point of view where BLACK PLAYS FIRST as in reality!
(hide) When moving in a game you can choose which one will show up next by selecting the appropriate option in the list next to the submit button. (pauloaguia) (show all tips)