volant: Yes, I think it is. Occasionaly, you can use it to scan your registry and delet needless paths and keys in registry.

Furthermore, I have a good experiences using Advanced Uninstaller 2006 instead of using remove programsa app. in control panel in windows. It deletes you all trash of application you want to be deleted, than scan your registry and finaly deleted all uncessery keys in it (or created when installing prog).
that is what I can really recommend and this way you can preced to overload your registry in Win.